Blocking Out the Palm

1) Start with a polygon cube that is 1 x 1 x 1 and has 1 subdivision in height, width, and depth.

2) Select the right face on your cube and extrude once. Use the move tool to drag the new face out in X. Then select the four vertices of that face and scale them in together in Z.

3) Extrude that face one more time and move it in X until it is about 3 times the length of the first extrusion. Then add an edge loop 1/3 of the way along the new section.

4) Select the three faces on the pinky side of the hand and extrude them once. After you extrude but before you move the faces you'll need to click the double circle. (This changes how the extruded faces move - it makes them move in world space instead of local space.) Then move them straight out toward the pinky.

5) Move the vertices closest to the base of the hand up so there starts to be some shape on the pinky side of the hand. Then select the face that is still straight and extrude and move it out twice.

6) Now delete the faces in between the vertices you moved up and the faces you extruded out.

7) Move the bottom vertices from the newly extruded section so they're almost on top of the vertices you moved up. Then use the Merge Edge (found in menu Edit Mesh --> Merge Edge Tool) tool to merge the edges together.

8) Select the three faces on the other side of the hand. Extrude and move them out to the edge of where you want your thumb to start. (Make sure before you move that you click the double circle to move in world space.)

9) Add four edge loops in the places shown.

10) Then reposition the vertices in top view so that they look like this.

Tip: When moving vertices in the top view make sure to drag over the vertices to select rather than clicking on specific ones. This allows you to select all the vertices from the top to bottom of the hand.